This statement hit my ears funny the first time i heard it. John Calvin talks about this in his institutes. I thought," How could God leave us a witness that was not perfect? If in fact the Bible is infallible, is not His Witness in nature as well? If so, how can it be infallible and not save? Isn't God's form of communication perfect?
Answer:
God's Witness in nature is not only perfect, it's totally infallible. General Revelation and special Revelation are not equa, but they are both inspired by God. Romans 1 tells us that what is to be known of God is clearly seen by the things made (us), and so we are without excuse; hence, it's enough to condemn--yet, it's not able to save. How can that be you ask? Well, it's our fault! Had mankind not fell, had Adam not sinned, we would know God through the creation perfectly; but we are fallen, and it's due to our dullness that we cannot see the God of scripture through nature.
God gives his revelation to man. We turn from it and claim it came from nothing instead. I think condemnation, due to the witness of nature along with our sin, is perfectly reasonable.